Successful Food-energy-water (FEW) nexus projects will be more likely to succeed if a transdisciplinary approachis used. Ecological modernization (ecological technology) policies and practices, and sustainable supply chainsinfluence the FEW nexus from a commerce and industry perspective. Taking these perspectives and consideringtheir intertwined linkages is important for advancing research and adoption of FEW nexus efforts. This paperprovides an overview of these perspectives and interlinkages. A biosolids case study is used to exemplify thecomplexities and interactions of these four thematic perspectives: the FEW nexus, transdisciplinarity, ecologicalmodernization, and sustainable supply chains. An integrative multi-level analysis scheme is used to analyzeinterrelationships. This analysis and the case study help to identify a series of research opportunities to furtherthis nascentfield. Research opportunities include methodological developments, attitudinal and social concerns,performance indicator systems, and meta-social evolutions in technology and policy.