عنوان مقاله | |
عنوان مقاله |
Exploiting the natural product potential of fungi with integrated-omics and synthetic biology approaches |
عنوان فارسی مقاله | بهره برداری از پتانسیل محصول طبیعی قارچها با رویکردهای بیولوژیک مصنوعی و زیست شناسی مصنوعی |
مشخصات مقاله انگلیسی | |
نشریه: Elsevier | |
سال انتشار |
2017 |
عنوان مجله |
Current Opinion in Systems Biology |
تعداد صفحات مقاله انگلیسی | 7 |
رفرنس | دارد |
تعداد رفرنس | 79 |
چکیده مقاله | |
چکیده |
Fungi are rich, underexploited reservoirs for natural products that may serve as medicines, commodity chemicals, in- secticides, pesticides and other valuable chemicals. Moreover, the biochemistry of natural product formation may be repur- posed with emerging synthetic biology tools to make valuable non-natural compounds such as biofuels. However, the path- ways that lead to these products are poorly understood and frequently inactive under lab conditions making discovery challenging. Recent advances in -omics approaches and synthetic biology tools provide powerful new methods to elucidate and tap this wealth of novel chemistry. In this review, we describe cutting-edge approaches to activate and charac- terize natural product formation, and discuss the potential of established and emerging fungal systems for natural product discovery. |
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