دوشنبه 17 اردیبهشت 1403
| عنوان مقاله | |
| عنوان مقاله |
Structural and chemical biology of deacetylases for carbohydrates, proteins, small molecules and histones |
| عنوان فارسی مقاله | زیست شناسی ساختاری و شیمیایی دیاستیلازها برای کربوهیدرات ها ، پروتئین ها ، مولکول های کوچک و هیستونها |
| مشخصات مقاله انگلیسی | |
| نشریه: NATURE |
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| سال انتشار |
2018 |
| عنوان مجله |
Communications biology |
| تعداد صفحات مقاله انگلیسی | 11 |
| رفرنس | دارد |
| تعداد رفرنس | 90 |
| چکیده مقاله | |
| چکیده |
Deacetylation is the removal of an acetyl group and occurs on a plethora of targets and for a wide range of biological reasons. Several pathogens deacetylate their surface carbohydrates to evade immune response or to support biofilm formation. Furthermore, dynamic acetylation/deacetylation cycles govern processes from chromatin remodeling to posttranslational modifications that compete with phosphorylation. Acetylation usually occurs on nitrogen and oxygen atoms and are referred to as N- and O-acetylation, respectively. This review discusses the structural prerequisites that enzymes must have to catalyze the deacetylation reaction, and how they adapted by formation of specific substrate and metal binding sites. |
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| دانلود | |
